• Intensive Care Unit, Huaihua Second People’s Hospital. Huaihua, Hunan, 418000, ChinaCorresponding Author: ZHENG Da-wei, E-mail: zhdw1218 @ 163. com;
Export PDF Favorites Scan Get Citation

Objective  To estimate the feasibility and efficacy of respiratory function score ( RFS)guided ventilator weaning in mechanical ventilated patients with respiratory failure. Methods  By a prospective control study,136 patients with acute respiratory failure who had received endotracheal intubation and mechanical ventilation from January 2010 to May 2012 were randomly divided into three group, ie. a RFS-guided 3-4 group ( n=60) , a RFS-guided 5-6 group ( n = 51) , and a traditional group ( n =25) . The
RFS-guided groups underwent ventilator weaning by guidance of RFS 3-4 and 5-6 respectively. The traditional group underwent ventilator weaning by ordinary way. The ventilation and oxygenation index, RFS,direct weaning success rate, total weaning success rate, total mechanical ventilation time, re-intubation rate,and ventilator-associated pneumonia ( VAP) incidence rate were observed.
Results  The direct weaning success rate in the RFS-guided 3-4 group, the RFS-guided 5-6 group, and the traditional group was 98. 3%( 59/60) , 82. 4% ( 42 /51) , and 100% ( 25 /25) , respectively. The total duration of mechanical ventilation was ( 5. 2 ±2. 5) days, ( 5. 0 ±3. 0) days, and( 7. 5 ±3. 5) days, respectively. the re-intubation rate was 0( 0 /60) , 1. 9% ( 1 /51) , and 0 ( 0/25) , respectively. VAP incidence rate was 11. 7% ( 7/60) , 13. 7%
( 7 /51) and 24% ( 6 /25) , respectively. Compared with the traditional group, the direct weaning success rate and total weaning success rate in the RFS-guided 3-4 group were not significant different( P  gt;0. 05) , while the total mechanical ventilation time and VAP incidence rate were significantly lower ( P  lt; 0. 05) . Compared with the traditional group, the direct weaning success rate and total mechanical ventilation time in the RFSguided 5-6 group were significantly lower ( P  lt;0. 05) , but the total weaning success rate was not significantly different ( P  gt;0. 05) . Compared with the RFS-guided 5-6 group, the directweaning success rate in the RFSguided 3-4 group was significantly increased.
Conclusions  Mechanical ventilator weaning of patients with respiratory failure under RFS guidance is safe and feasible. RFS 3-4 guided ventilator weaning can significantly improve the therapeutic effect.

Citation: ZHENG Dawei,ZENG Xiangbin,GAO Feng,LIU Renshui,XIONG Wei,DENG Shunlian,PENG Meihua.. Respiratory Function Score Guided Ventilator Weaning in Patients with Respiratory Failure. Chinese Journal of Respiratory and Critical Care Medicine, 2013, 12(2): 146-149. doi: DOI: 10 . 7507 /1671 -6205 . 20130034 Copy

Copyright © the editorial department of Chinese Journal of Respiratory and Critical Care Medicine of West China Medical Publisher. All rights reserved

  • Previous Article

    The role of Interleukin-10 in Airway Inflammation in COPD Rats
  • Next Article

    Application of Lidocaine via Nebulization during Mechanical Ventilation in Intensive Care Unit